Osteoarthritis of the knee
Conditions
Interventions
Group A:No adrenaline
Group B:Adrenaline 0.3 mg
Group C:Adrenaline 0.5 mg
Sponsors
Qilu Hospital of Shandong University (Qingdao)
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years old, no language communication and cognitive impairment before operation; 2. Patients who are scheduled to undergo knee replacement; 3. American Society of Anesthesiologists ASA Class I, II, III; 4. Operated by the same joint surgeon team; 5. Clearly understand and voluntarily participate in the study, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those who cannot cooperate with combined spinal epidural anesthesia, such as previous history of severe mental or neurological diseases, high bleeding risk, nerve damage, etc.; 2. The skin around the nerve block puncture point is infected; 3. Patients who are allergic to local anesthetics; 4. Patients who do not need a tourniquet during the operation; 5. Patients with atrial fibrillation or other arrhythmias before surgery, patients with unstable angina pectoris and a history of myocardial infarction before surgery; 6. Patients with post-traumatic arthritis, secondary arthritis or simultaneous bilateral total knee arthroplasty; 7. Participated in other clinical trials within 30 days; 8. Other reasons that the investigator thinks it is inappropriate to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| systolic pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Other intraoperative hemodynamic indexes;Intervention of vasoactive drugs;Postoperative pain score;Wound drainage;Quadriceps muscle strength score;degree of satisfaction;hospital stay; | — |
Countries
China
Contacts
Public ContactJinfeng Zhou
Qilu Hospital of Shandong University (Qingdao)
Outcome results
None listed