H. pylori infection
Conditions
Interventions
Experimental group:BQT for 14 days and supplemented with probiotics
Control group:BQT for 14 days and supplemented with placebo
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Positive rapid urease test and 13C-urea breath test (13C-UBT); 2. Age 18-65 years; 3. Did not use antacids or gastric mucosal protection drugs, antibiotics or probiotics in the past month; 4. During the study period, any special dietary intervention, especially products containing probiotics, cannot be carried out; 5. The legal representative or guardian of the patient voluntarily agrees and signs the informed consent form, and can abide by the research protocol during the research period.
Exclusion criteria
Exclusion criteria: 1. Patients with any of the following diseases were excluded from the study: history of gastrectomy, previous Helicobacter pylori eradication therapy, peptic ulcer or other upper gastrointestinal lesions, gastrointestinal malignancies; 2. Contraindications or allergic reactions to the study drugs in the past; 3. Use of antacids or gastric mucosal protection drugs, antibiotics or probiotics in the past month; 4. Those who have a recent history of glucocorticoids and immune preparations; 5. Pregnant or lactating women; 6. History of intolerance or allergy to probiotics; 7. Patients who cannot express their subjective feelings correctly and cannot cooperate; 8. Participate in another clinical study within 6 months before the start of the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantitative subgenomic alterations in bacterial genes and species;Intestinal metabolites; | — |
Secondary
| Measure | Time frame |
|---|---|
| Markers of inflammation;Intestinal barrier function;Gastrointestinal symptom score;13C-urea respiration test;Food Frequency Questionnaire; | — |
Countries
China
Contacts
Public ContactHan Ting
Shanghai Tenth People's Hospital
Outcome results
None listed