Effective concentration of ciprofol required to prevent cardiovascular response to tracheal intubation when induced with remimazolam

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200063712

Enrollment

Unknown

Registered

2022-09-15

Start date

2022-10-01

Completion date

Unknown

Last updated

2023-04-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Drug dosage of ciprofol during induction of anesthesia

Interventions

Group 1 :Adjust the drug dose according to the response to tracheal intubation

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Patients selected for elective surgery under general anesthesia from July 2022 to September 2022; 2. Patients aged between 18 and 60 years, male or female, weighed 50 to 80 kg; 3. American Association of Anesthesiologists (ASA) grade I or II.

Exclusion criteria

Exclusion criteria: 1. Preoperative SBP >= 180 mmHg, DBP >= 110 mmHg; 2. Past history of allergy to benzodiazepines; 3. Past history of taking long-time sedative analgesics; 4. Past history of alcohol abuse,neurological disorders, and severe depression.

Design outcomes

Primary

Measure	Time frame
Intubation response after induction;Half effective dose;95% effective dose;mean artery pressure;heart rate;	—

Countries

China

Contacts

Public ContactZhang Xiaobao

The Affiliated Lianyungang Hospital of Xuzhou Medical University

hotdog100@163.com+86 18961322507

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026