Infective endocarditis
Conditions
Interventions
Control Group:Surgical treatment of infective endocarditis
Treatment group:Surgical treatment of infective endocarditis+HA380 treatment
Sponsors
Drum Tower Hospital, School of Medicine, Nanjing University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) No restriction on gender, age over 18; 2) Infective endocarditis (IE), which meets the modified Duke diagnostic criteria and has surgical indications according to the 2015 European Society of Cardiology IE management guidelines; 3) Signed informed consent.
Exclusion criteria
Exclusion criteria: 1) Low-risk patients with EuroScore II =3 for cardiac surgery; 2) Currently participating in other clinical trials; 3) Patients allergic to hemoperfusion, filter and anticoagulant; 4) Patients who were pregnant or suspected of being pregnant or breastfeeding at the time of inclusion; 5) Patients with malignant tumor or connective tissue disease; 6) Patients with rheumatic immune diseases; 7) Infective endocarditis with systemic immune response; 8) Liver and kidney diseases before surgery. 9) The written consent of the patient or client cannot be obtained.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perioperative mortality;Rate of secondary thoracotomy;postoperative kidney failure;paraplegia;Stroke/cerebrovascular accident;Low cardiac output syndrome;Retracheal intubation;Severe liver dysfunction;ECMO;multiple organ dysfunction syndrome; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory factor;SOFA score;24 hours discharge;postoperative acute kidney injury;postoperative respiratory failure;postoperative delirium;postoperative liver injury;postoperative myocardial infarction;postoperative Mechanical ventilation time; | — |
Countries
China
Contacts
Public ContactLiu Chang
Drum Tower Hospital, School of Medicine, Nanjing University
Outcome results
None listed