postoperative cognitive dysfunction
Conditions
Interventions
lentinan group:intravenous infusion of lentinan
Sponsors
Sun Yat-sen Memorial Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Patients aged 60-75 who underwent elective laparoscopic abdominal surgery; (2) The duration of surgery and general anesthesia is more than 2 hours, and the postoperative hospital stay is at least 5 days; (3) No serious visual or auditory impairment, able to read text for neuropsychological tests; (4) No history of allergy to lentinan or severe allergy to other food and drugs. (5) The patients participated voluntarily and signed the informed consent.
Exclusion criteria
Exclusion criteria: (1) The score of the Simple Intelligence Scale Test (MMSE) [18] is lower than 23; (2) Have a history of dementia, mental illness or other central nervous system diseases; (3) Taking sedatives, antidepressants or hormones; (4) Those who have taken lentinan for the past three months; (5) Those who are addicted to alcohol or drugs; (6) The patient has been enrolled in this study before (applicable to the case where the patient underwent a second abdominal surgery during the study period); (7) Those who cannot conduct long-term follow-up or have poor compliance; (8) Anemia or thrombocytopenia, Hb180/100mmHg).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function; | — |
Secondary
| Measure | Time frame |
|---|---|
| inflammatory factor;Security indices; | — |
Countries
China
Contacts
Public ContactYujuan Li
Outcome results
None listed