Stroke
Conditions
Interventions
Part ?: Group 1:Paired associative stimulation
Part ?: Group 2:Sham stimulation
Sponsors
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Part I: (1) 18-70 years old, unlimited gender; (2) No neurological disease, no serious bone, joint or muscle diseases, no obvious cognitive impairment, no serious organ disease or serious mental disease; (3) right-handed. Part ?: (1) Ischemic/hemorrhagic stroke diagnosed by CT/MRI; (2) 30-70 years old, unlimited gender; (3) Primary education level or above; (4) First onset, course of disease within 1 year, unilateral hemiplegia; (5) No obvious cognitive impairment, mini-mental State Examination (MMSE) : primary education level: >20; Middle education level or ablove: >24; (6) Unilateral upper extremity motor dysfunction, the upper extremity of Fugl-Meyer Assessment Scale (FMA) : 0-65; (7) right-handed.
Exclusion criteria
Exclusion criteria: Part I: (1) There are contraindications, such as pacemaker, cardiac stent, claustrophobia, etc.; (2) Participated in or is participating in other clinical projects one month before enrollment; (3) There are contraindications to transcranial magnetic stimulation, such as cochlear implantation, history of epilepsy, metal implantation in vivo; (4) Pregnant or lactating women. Part ?: (1) Unstable vital signs in the acute phase; (2) Aphasia, hearing impairment and other people who are unable to communicate with others; (3) Severe bone, joint and muscle diseases; (4) Patients with serious organ diseases and mental disorders; (5) There are contraindications, such as pacemaker, cardiac stent, claustrophobia, etc.; (6) Participated in or is participating in other clinical projects one month before enrollment; (7) There are contraindications to transcranial magnetic stimulation, such as cochlear implantation, history of epilepsy, metal implantation in vivo; (8) Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Finger tapping test;Fugl-Meyer assessment scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neuroelectrophysiological indexes;Magnetic Resonance Imaging;Grip strength test;Simple test for evaluating hand function;Modified Barthel Index;stroke-specific quality of life; | — |
Countries
China
Contacts
Public ContactWu Jia-Jia
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine
Outcome results
None listed