major depressive disorder
Conditions
Interventions
prazosin group:prazosin
placebo grooup:placebo
Sponsors
Huzhou Third People's Hospital
Eligibility
Sex/Gender
All
Age
13 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) It meets the diagnostic criteria of dsm-5 for moderate / severe depression and is further verified by mini set clinical interview; (2) Han nationality; Both men and women, aged from 13 to 65; (3) HAMD-21 = 18 points, CGI-S = 3 points; (4) There are childhood (before the age of 17) trauma or recent (within 3 years) traumatic stress events. (5) Sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Schizophrenic affective psychosis, dysthymia or bipolar depression; Any anxiety disorder was the main diagnosis within 1 year; obsession; Patients with substance abuse or dependence; Personality disorders. (2) Various contraindications covered in the instructions for the use of prazosin, such as: allergy to prazosin, hypotension ( 100bpm), and large blood pressure difference in lying position( ? Systolic blood pressure > 20mmhg, ? Diastolic blood pressure > 10mmhg, or ? Mean arterial pressure > 20mmhg) or other people who are not suitable for this treatment are not included. (3) Pregnant or lactating women; (4) Patients with serious or unstable heart, liver, kidney, endocrine organs, blood, autoimmune diseases and other medical diseases; Patients with epilepsy or other brain organic diseases; Increased intracranial pressure, intractable and refractory hypertension, glaucoma, etc; (5) A serious history of attempted suicide, or there is a high risk of suicide at present, or the HAMD 3rd suicide score = 3; (6) NMDA receptor antagonists such as ketamine have been used in the past; (7) Systematic antipsychotic treatment was received 2 weeks before enrollment; (8) Those who have received electroconvulsive therapy, rTMS therapy or systematic psychotherapy in recent 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Totle score reduction of Hamilton Depression scale-17 items; | — |
Secondary
| Measure | Time frame |
|---|---|
| Montgomery-Asberg Depression Rating Scale;Columbia - suicide severity rating scale questionnaire;Hamilton Anxiety Scale;Clinical general impression scale;Digit Symbol Substitution Test;Perceived Deficit Questionnaire for Depression;QOL-BREF;SHEEHAN DISABILITY SCALE; | — |
Countries
China
Contacts
Public ContactShikai Wang
Huzhou Third People's Hospital
Outcome results
None listed