postoperative cognition in elderly patients
Conditions
Interventions
Propofol intravenous anesthesia group:Propofol intravenous anesthesia
Rebenine anesthesia group :Rebenine anesthesia
Sponsors
Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: standard constrain: (1) Patients = 60 years old who underwent elective laparoscopic abdominal surgery; (2) The duration of surgery and general anesthesia is more than 2 hours, and the postoperative hospital stay is at least 5 days; (3) No serious visual or auditory impairment, able to read text for neuropsychological tests; (4) Patients participated voluntarily and signed the informed consent.
Exclusion criteria
Exclusion criteria: Exclusion criteria: (1) MMSE score lower than 23 points; (2) Past history of dementia, mental illness, etc.; (3) Taking sedatives, antidepressants or hormones; (4) Those who are addicted to alcohol or drugs; (5) The patient has been enrolled in this study before; (6) Those who cannot conduct long-term follow-up or have poor compliance; (7) The general condition of the patient is poor, with a history of severe cardiovascular system, respiratory system, liver and kidney system, central nervous system and other diseases, May be difficult to survive for more than 3 months; (8) The patient's preoperative blood pressure was poorly controlled (preoperative baseline value>180/100mmHg). (9) The patient has a history of allergy to propofol or benzodiazepines.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cognitive function; | — |
Secondary
| Measure | Time frame |
|---|---|
| inflammatory factors;Security indices; | — |
Countries
China
Contacts
Public ContactYujuan Li
Outcome results
None listed