general anesthesia
Conditions
Interventions
CIP1:ciprofol 0.25mg/kg
CIP2:ciprofol 0.3mg/kg
CIP3:ciprofol 0.35mg/kg
PROP:propofol1.5mg/kg
Sponsors
General Hospital of Northern Theater Command
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: a) Age = 65 years old, regardless of gender; b) Patients scheduled for elective endotracheal intubation under general anesthesia; c) ASA grade ? ~ ?; d) BMI 18-30kg/m2; e) Voluntary signing of Informed Consent Form.
Exclusion criteria
Exclusion criteria: a) Known hypersensitivity to the active ingredient (s) or excipient (s) of cyclopofol or propofol injection; b) Difficult airway patients, patients with modified Mallampati classification ?; c) Pregnant or lactating patients; Patients with planned pregnancy within 1 month after operation; d) Severe cardiovascular system, respiratory system, nervous system, liver and kidney diseases before operation; Patients with blood and metabolic diseases; e) Patients with severe disturbance of consciousness or mental system diseases (schizophrenia, mania, bipolar disorder, mental disorder, etc.) And cognitive dysfunction; f) Long-term smokers, drinkers and drug abusers; Patients with a history of sedative/anesthetic use within 1 month; g) Patients with significantly abnormal preoperative physical or laboratory findings.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| success rate of induction in general anesthesia;The maximum decrease in systolic blood pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| time of successful induction of general anesthesia;Time of disappearance of eyelash reflex;change of BIS value; | — |
Countries
China
Contacts
Public ContactDiao Yugang
Outcome results
None listed