Ovarian dysfunction
Conditions
Interventions
Group N1:Patients receiving GH are going to be administered 18 IU/week sc on Day2 or Day3 of the previous menstrual cycle before IVF. After about 6 administrations, patients can receive 4 IU/day GH sc
Group N2:Patients in Group N2 will start controlled ovarian hyperstimulation after being grouped without preliminary GH administration.
Sponsors
Reproductive medicine center of Guangdong Women and Children Hospital
Eligibility
Sex/Gender
Female
Age
35 Years to 42 Years
Inclusion criteria
Inclusion criteria: 1. Infertile women planning IVF / ICSI for the first time; 2. Age: 35-42 years old; 3. GH has not been used in the past 2 months.
Exclusion criteria
Exclusion criteria: 1. AMH <0.2 ng/mL; 2. Patients unable or unwilling to participate in the trial; 3. Patients with GH-prohibited diseases, such as diabetes, severe systemic infections, active tumors, etc.; 4. Patients participating in other clinical studies at the same time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative live birth rates; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of retrieved oocytes;Number of mature eggs;Number of fertilized eggs;Number of cleaved embryos;Number of high-quality embryos;Endometrial thickness on hCG day;Implantation rate;Mild to severe OHSS;Viable intrauterine pregnancy;Ectopic pregnancy;Abortion;Stillbirth;Terminal pregnancy;Live birth;Gestational age at birth;Birth weight;Neonatal mortality;Important congenital malformations;cleavage rate;high-quality embryo rate;clinical pregnancy rate;ongoing pregnancy rate;cycle cancellation rate;Ectopic pregnancy rate;miscarriage rate;live birth rate;risk of low birth weight;preterm birth rate;OHSS incidence; | — |
Countries
China
Contacts
Public ContactFenghua Liu
Reproductive medicine center of Guangdong Women and Children Hospital
Outcome results
None listed