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Pathogenesis research of tumorigenesis and progression of colorectal cancer modulated by gingipains secreted by Porphyromonas gingivalis

Porphyromonas gingivalis modulates tumorigenesis and progression of colorectal cancer via gingipains:A case-control study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200063587
Enrollment
Unknown
Registered
2022-09-12
Start date
2022-09-12
Completion date
Unknown
Last updated
2023-04-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Cancer

Interventions

Aspirin group:Not applicable
Non-Aspirin group:Not applicable

Sponsors

Division of Gastrointestinal Surgery, Department of General Surgery, West China Hospital, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1) Histologically proven colorectal adenocarcinoma; 2) Paired tumor and normal adjacent tissue (NAT) samples.

Exclusion criteria

Exclusion criteria: 1) Past medical history of inflammatory bowel disease (IBD); 2) Received oral or intravenous antibiotics therapy longer than 3 days in the past 1 month; 3) Received neoadjuvant treatment, including chemotherapy, radiotherapy, and immunotherapy and etc.; 4) Samples from colonoscopy biopsy or local resection (endoscopic submucosal dissection or transanal resection).

Design outcomes

Primary

MeasureTime frame
Abundance of Porphyromonas gingivalis (Pg) in samples;—

Secondary

MeasureTime frame
3-year overall survival rate;—

Countries

China

Contacts

Public ContactLie Yang

Division of Gastrointestinal Surgery, Department of General Surgery, West China Hospital, Sichuan University

lie_222@163.com18980602267

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026