Colorectal cancer
Conditions
Interventions
Control group (CON group):Intravenous and inhalation combined anesthesia, equal amount of normal saline
Sufentanil PCIA.
Dexmedetomidine group (DEX group):Dexmedetomidine group (DEX group): intravenous anesthesia was assisted by intravenous of DEX with the loading dose of 0.5~1.0 microgram/kg completed within 10 minutes
Epidural group (EP group):Intravenous Inhalation Combined with epidural anesthesia, ropivacaine + sufentanil PCEA
DEX + EP group:Intravenous anesthesia assisted by intravenous DEX combined with epidural anesthesia, ropivacaine + DEX PCEA.
Sponsors
Shaoxing people's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Male or female patients aged between 18 and 75; 2) Body mass index (BMI) is between 18 and 30; 3) Laparoscopic radical resection of colorectal cancer under ASA I-II general anesthesia; 4) Agreed to participate in the experiment and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1) Heart rate is lower than 55 beats/ min or stage III hypertension; 2) Diabetes or difficult airway; 3) Patients with heart, liver, kidney or immune system diseases; 4) Patients with neurological disease, language disorder and hearing impairment who cannot communicate and cooperate. 5) Patients with systemic infection (body temperature higher than 38 ?), blood system disease, coagulation dysfunction, infection at epidural puncture site, anticoagulant treatment, etc. who do not meet the requirements of epidural puncture; 6) Patients with allergic constitution; 7) Pregnant women or breast-feeding patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peristalsis time after operation;Oral feeding time after operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| D-lactic acid;FABP2;SCD1;DAO;LPS;MDA;TNF-a;IL-6;Immune indicators: T cells (CD3), helper/induced T cells (CD4), inhibitory / cytotoxic T cells (CD8), NK cells, total B cells (CD19) and CD4/CD8 ratio;Arterial blood environmental indicators: arterial blood gas, electrolyte and acid-base balance;;Hemodynamic indexes: BP, CVP;Intraoperative fluid volume;Dose of narcotic drugs;;Blood biochemical indexes before and 1 day after operation;;According to the international surgical outcomes study (ISOs) standard, the in-hospital complications and mortality of patients 30 days after surgery were investigated;Investigation of postoperative analgesia effect; | — |
Countries
China
Contacts
Public ContactRui He
Outcome results
None listed