Effect of polyunsaturated fatty acids on postoperative delirium and postoperative cognitive dysfunction

Relationship between serum polyunsaturated fatty acid levels and perioperative neurocognitive dysfunction

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200063508

Enrollment

Unknown

Registered

2022-09-09

Start date

2022-09-10

Completion date

Unknown

Last updated

2023-04-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative neurocognitive dysfunction

Interventions

None listed

Eligibility

Sex/Gender

All

Age

65 Years to 95 Years

Inclusion criteria

Inclusion criteria: 1. The patient's age is 65 or older; 2. Elderly patients undergoing joint replacement under general anesthesia, including hip replacement and knee replacement; 3. ASA grade is I-III; 4. The estimated survival time is longer than 12 months; 5. Signed Informed consent.

Exclusion criteria

Exclusion criteria: 1. Emergency surgery patients; 2. Hyperlipidemia or complicated with severe heart, lung, liver, and renal insufficiency; 3. Severe audio-visual impairment or communication difficulties; 4. Illiterate or undereducated, unable to complete scale test; 5. Mini-mental State Examination (MMSE) score < 24 or a history of dementia, neurological or mental illness for any reason; 6. Alcohol or drug abusers.

Design outcomes

Primary

Measure	Time frame
Mini-mental State Examination;3-Min Diagnostic Interview for CAM-defined Delirium;Telephone Interview for Cognitive Status;Montreal Cognitive Assessment;Memorial Delirium Assessment Scale;Polyunsaturated fatty acids;IL-6;IL-1ß;	—

Countries

China

Contacts

Public ContactXiaoping Gu

Affiliated Drum Tower Hospital, Medical School of Nanjing University

xiaopinggu@nju.edu.cn+86 13813996903

Outcome results