Gynecological oncology, endometriosis, breast cancer, hemopathy, etc.
Conditions
Interventions
Group 1:Fresh ovarian tissue was stored in vitro at low temperature for 24 hours
Group 2:Fresh ovarian tissue was stored in vitro at low temperature for 30 hours
Group 3:Fresh ovarian tissue was stored in vitro at low temperature for 48 hours
Sponsors
Beijing Obstetrics and Gynecology Hospital, Capital Medical University
Eligibility
Sex/Gender
Female
Age
No minimum to 37 Years
Inclusion criteria
Inclusion criteria: 1. The age is not more than 37 years old in principle. The age limit can be appropriately relaxed according to the ovarian reserve function and personal wishes; 2. Due to the primary disease and its treatment, patients who need radiotherapy, chemotherapy, or other patients with a high risk of POI in the short term; 3. The prognosis of the primary disease is good, and the 5-year survival rate is higher; 4. At least three days before the start of radiotherapy and chemotherapy; 5. Can tolerate laparoscopic or open ovarian tissue sampling surgery; 6. The patient signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. The ovarian reserve function was low and had developed to POI; 2. Ovarian malignant tumor occurred before cryopreservation, or the primary ovarian metastasis was suspected by imaging; 3. The patients were in the poor physical condition and could not tolerate the operation of ovarian tissue sampling.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| follicle viability;follicle morphology;cell apoptosis;tumor necrosis factor a;B-cell lymphoma-2;bone morphogenetic protein 15;growth differentiation factor 9; | — |
Countries
China
Contacts
Public ContactXiangyan Ruan
Beijing Obstetrics and Gynecology Hospital, Capital Medical University
Outcome results
None listed