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Based on the theory of brain-gut axis to analyze the effect of the Wu Yin Tiao Shen therapy on post-stroke (mild to moderate) depression

Based on the theory of brain-gut axis to analyze the effect of the Wu Yin Tiao Shen therapy on post-stroke (mild to moderate) depression

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200063472
Enrollment
Unknown
Registered
2022-09-07
Start date
2022-09-07
Completion date
Unknown
Last updated
2023-04-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

post-stroke depression

Interventions

Sponsors

The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Meeting the cranial CT or MRI diagnostic imaging criteria for stroke, as well as the Chinese and Western medical diagnostic criteria for depression; 2. With gastrointestinal symptoms, a HAMD-17 score of 1 for a single gastrointestinal symptom, and secondary to PSD gastrointestinal symptoms; 3. Aged 18-75 years, regardless of gender; 4. The onset of PSD is 2–36 weeks after the stroke; 5. PSD severity is mild to moderate, i.e., a score of 8-24 on the HAMD-17 scale; 6. Sign the form requesting informed consent.

Exclusion criteria

Exclusion criteria: 1. HAMD-17 score for suicidal ideation with a single factor score of >= 3; 2. Patients with fluctuating vital signs or severe cardiac, hepatic, or renal failure; 3. Patients with severe cognitive impairment, aphasia, or audiovisual dysfunction cannot complete the assessment; 4. patients who have recently experienced significant trauma and are dependent on alcohol or drugs; 5. Patients on antidepressant medication who have a history of major depression; 6. Patients with organic gastrointestinal lesions; 7. Patients with dementia, Parkinson's disease, epilepsy, etc., may affect the assessment of the severity of PSD; 8. Patients who are averse or unacceptable to music and for whom there are contraindications to acupuncture treatment should be excluded.

Design outcomes

Primary

MeasureTime frame
Hamilton Depression Scale-17;

Secondary

MeasureTime frame
Gastrointestinal symptom scale;National Institutes of Health Neurological Impairment Score;Post-stroke specific quality of life scale;

Countries

China

Contacts

Public ContactZiyun Feng

The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine

15064029536@163.com+86 13021738771

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026