The effect and mechanism of folic acid intervention on stroke patients with cognitive impairment

The mechanism of folic acid on cognitive function after cerebral infarction based on lncRNA and NMDA receptor regulation of synaptic plasticity

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200063437

Enrollment

Unknown

Registered

2022-09-06

Start date

2022-09-01

Completion date

Unknown

Last updated

2023-04-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stroke

Interventions

folic acid group:folic acid

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. First onset ischemic stroke; 2. Glasgow Coma Scale score between 9 and 15; 3. Montreal Cognitive Assessment score below 27; 4. Aged 18-80 years.

Exclusion criteria

Exclusion criteria: 1. Cerebral hemorrhage, intracranial tumors, intracranial vascular malformations; 2. Patients with malignant tumors; 3. Liver and kidney and other organ dysfunction; 4. Patients with severe megaloblastic anemia; 5. The use of drugs that may affect Hcy levels, such as B vitamins; 6. Prehospital thrombolysis, interventional therapy patients; 7. Severe dementia and aphasia affected the investigation and evaluation of the respondents; 8. Patients with a family history of mental illness or mental illness; 9. Cases of occupational exposure to toxic and harmful substances.

Design outcomes

Primary

Measure	Time frame
HCY;folate;	—

Countries

China

Contacts

Public ContactZhongying Gong

Tianjin First Central Hospital

13212121250@163.com+86 13212121250

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026