Drug-resistant Mycoplasma pneumoniae pneumonia in children
Conditions
Interventions
experimental group:Macrolide antibiotics in intravenous drip and Qushi Tongluo formula granule oral
control group:Macrolide antibiotics in intravenous drip and Qushi Tongluo formula granule 1/4 oral
Sponsors
Affiliated Hospital of Shandong University of Traditional Chinese medicine
Eligibility
Sex/Gender
All
Age
1 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1. Patients who met the Western diagnostic criteria for drug-resistant Mycoplasma pneumoniae pneumonia; 2. Patients who met the TCM syndrome differentiation and diagnosis criteria of damp-heat pulmonary closure syndrome; 3. Hospitalized children aged 1-12 years; 4. The process of informed consent complies with the provisions, and the legal representative signs the informed consent (children aged >= 8 years shall also sign the informed consent).
Exclusion criteria
Exclusion criteria: 1. Chest X-ray showed obvious lung tumor and tuberculosis; 2. Measles, whooping cough, influenza and other acute infectious diseases; 3. Acute upper respiratory tract infection, wheezing bronchitis, bronchial asthma, bronchial foreign body and other respiratory diseases; 4. Children with severe malnutrition and immunodeficiency; 5. Complicated with severe primary diseases of heart, liver, kidney, digestive and hematopoietic systems; 6. Patients who have participated in or are participating in clinical trials of other drugs in the past three months; 7. Allergic constitution (allergic to more than 2 kinds of substances), or allergic to macrolides and Qushi Tongluo formula and its components; 8. Participants deemed unsuitable for inclusion by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The total effective rate of disease;Time for complete reduction of fever;Antipyretic onset time;Effective time of cough;Effective time of expectoration;Curative effect of TCM syndrome;Efficacy of symptom improvement;Efficacy of improvement of pulmonary signs; | — |
Secondary
| Measure | Time frame |
|---|---|
| T lymphocyte subsets levels;Immunoglobulin levels;C-reactive protein levels;Interleukin-6 levels; | — |
Countries
China
Contacts
Public ContactGuangyuan Jia
Outcome results
None listed