Primary Membranous Nephropathy
Conditions
Interventions
RT-R :Rituximab combined with tacrolimus induction + rituximab maintenance
RT-T:Rituximab combined with tacrolimus induction + tacrolimus maintenance
PC-C:Glucocorticoid combined with cyclophosphamide induction + maintenance
Sponsors
Renji Hospital Affiliated to Shanghai jiao tong university school of medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. gender is not limited; 2. Age 18-75 3. Kidney biopsy pathology suggests primary membranous nephropathy; 4. Serological or histological PLA2R positive; 5. 24-hour urine protein quantification >= 3.5g/d and serum albumin = 45ml/min/1.73m2;
Exclusion criteria
Exclusion criteria: 1. Secondary membranous nephropathy (tumor-related, lupus-related, hepatitis B-related, infection-related, drug-related, etc.); 2. Renal biopsy pathology showed severe tubulointerstitial lesions; 3. Severe infection, severe cardiac insufficiency, severe hepatic insufficiency, gastrointestinal bleeding, ketoacidosis and other life-threatening complications within one month; 4. Glucocorticoids and/or immunosuppressive therapy (cyclophosphamide, MMF, tacrolimus) within 3 months; 5. have a history of kidney transplantation; 6. breastfeeding or pregnant women; 7. Patients with mental disorders or unable to cooperate ;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24h UTP;Scr;PLA2R;Alb; | — |
Countries
China
Contacts
Public ContactQin Wang
Renji Hospital Affiliated to Shanghai jiao tong university school of medicine
Outcome results
None listed