Atopic Dermatitis (AD)
Conditions
Interventions
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
0.5 Years to 5 Years
Inclusion criteria
Inclusion criteria: 1. 6 months 50 points or EASI score > 20 points or IGA >= 4 points; 4. Poor response or intolerance to at least one topical drug (such as glucocorticoid, calcineurin inhibitor, phosphodiesterase inhibitor, etc.) in recent 6 months; 5. The guardian has signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Older than 6 years old; 2. Active chronic or acute infection requires systemic antibiotics and antiviral therapy within two weeks before the baseline visit;Patients treated with drugs, antigenic drugs or antifungal drugs were treated with TCI within 2 weeks before the baseline visit; 3. Patients who are vaccinated or ready to be vaccinated with live vaccine or attenuated live vaccine within 4 weeks; 4. Patients with primary / secondary immunodeficiency or suspected immunodeficiency; 5. Except for patients with genetic metabolic diseases, seborrheic dermatitis and other diseases that need to be identified; 6. Those who are allergic to doprilumab and any of its components; 7. According to the judgment of the researcher, the supervisor is untrustworthy or has poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eczema Area and Severity Index (EASI);Investigator Global Assessment (IGA) 0 or 1; | — |
Secondary
| Measure | Time frame |
|---|---|
| SCORing of Atopic Dermatitis;Patient-reported Outcome of Eczema Mesure Score;The Children's Dermatitis Quality of Life Index;Infants Dermatitis Quality of Life Index;Peak Pruritus Numerical Rating Scale (NRS);Atopic Dermatitis Control Tool; | — |
Countries
China
Contacts
Public ContactHua Wang
Children's Hospital of Chongqing Medical University
Outcome results
None listed