None listed
Conditions
Interventions
esketamine group:0.2mg/ Ketamine was given intravenously during anesthesia induction, and 0.2mg/kg was added every 30 minutes to maintain anesthesia,30min stops administration before the end of the op
Control group:The corresponding dose of normal saline was given at the same time.
Sponsors
General Hospital of the Western Theater of the Chinese people's Liberation Army
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Over 18 years old 2. Patients who underwent elective radical resection of gastrointestinal tumors 3. The function of liver and kidney is normal 4. Blood clotting function is normal 5. ASA grade I-III 6. Obtain the informed consent of the patient
Exclusion criteria
Exclusion criteria: 1. Patients who are allergic to experimental drugs 2. Patients with uncontrolled hypertension and coronary heart disease 3. Unable to communicate before operation (coma, deep dementia, language disorder, mental disorder or mental disorder) 4. There are infectious diseases and blood system diseases 5. Increase of blood lactic acid or metabolic disorder 6. Suffering from end-stage chronic disease 7. Severe pulmonary hypertension 8. Patients with heart failure or acute myocardial infarction 9. Without the informed consent of the patient
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Systolic blood pressure;Diastolic pressure;Mean arterial pressure;heart rate;Adrenocorticotropic hormone;Adrenaline;Norepinephrine;IL-6;C-reactive protein; | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of stay in hospital;Nausea and vomiting;Dizziness and drowsiness; | — |
Countries
China
Contacts
Public ContactGu Gong
General Hospital of the Western Theater of the Chinese people's Liberation Army
Outcome results
None listed