To explore the molecular mechanism of Lingzhu granule in the treatment of phlegm dampness polycystic ovary syndrome based on the change of microbial flora

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200063375

Enrollment

Unknown

Registered

2022-09-05

Start date

2022-09-05

Completion date

Unknown

Last updated

2023-04-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic ovary syndrome

Interventions

Chinese medicine group:Lingshu granule

control group:Metformin Hydrochloride Tablets

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Women aged 18-35 years old had normal liver and kidney functions; 2. Meet the Rotterdam diagnostic criteria for PCOS; 3. It meets the diagnostic criteria of phlegm dampness syndrome of TCM.

Exclusion criteria

Exclusion criteria: 1. Antibiotics and other drugs used in the past 1 month, oral contraceptives, glucocorticoids, anti androgens, ovulation stimulating drugs, diabetes drugs or other steroids taken within 3 months; 2. Fever, gastrointestinal disease and active infection occurred during sampling; 3. Patients with hyperprolactinemia, hypothyroidism or hyperthyroidism, severe disorders of liver, kidney and hematopoietic system, infectious diseases or psychosis, hypertension or diabetes; 4. Pregnant or lactating women.

Design outcomes

Primary

Measure	Time frame
Microbial composition of the digestive tract;Biochemical Indicators;Fecal microorganisms;	—

Secondary

Measure	Time frame
Objectify tongue image parameters;TCM Syndrome Scale;BMI;WC;Hips;	—

Countries

China

Contacts

Public ContactMin Xu

Guangzhou University of traditional Chinese Medicine

Xumin3333@163.com+86 13922310114

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026