Preterm birth
Conditions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Pregnant women who received regular obstetric examinations and delivered in Fujian Maternal and Child Health Hospital; 2. Twin pregnancy; 3. Signed informed consent; 4. Painless dilatation of the cervical os, with or without a herniated amniotic sac, found in the second trimester; 5. The follow-up compliance was good.
Exclusion criteria
Exclusion criteria: 1. Latrogenic preterm birth factors; 2. Singleton pregnancy; 3. Systemic and reproductive tract infections; 4. Fetal chromosomal abnormalities or congenital malformations; 5. Fetal growth restriction; 6. Genital malformations; 7. Abnormal position of the placenta; 8. Pregnancy complications: gestational hypertension, ICP, stillbirth, etc.; 9. Pregnancy complications: obesity, diabetes, hypertension, autoimmune disease, thrombophilia, digestive system disease, malignant tumor, etc.; history of digestive tract surgery; 10. Poor follow-up compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gestational age at delivery;live birth rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fetal weight;Neonatal morbidity;NICU admission rate; | — |
Countries
China
Contacts
Department of Obstetrics, Fujian Maternity and Child Health Hospital Affiliated to Fujian Medical University