Intraoperative sedation
Conditions
Interventions
group 1:Intravenous infusion of remimazolam at a constant rate
group 2:Target controlled infusion of Remimazolam
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Stage 1: 1. ASA grade 1; 2. Who proposed a bilateral hallux valgus osteotomy under lumbar-hard combined anesthesia; 3. Aged 18–65 years; 4. Body mass index of 18 – 30 kg/m2; 5. Signed the informed consent. Stage 2: 1. ASA grade 1; 2. Who planned to undergo elective lower limb surgery under lumbar-hard combined anesthesia; 3. Aged 18–65 years; 4. Body mass index of 18 – 30 kg/m2; 5. Signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. A history of central nervous system diseases; 2. Hypertension or coronary artery disease or congestive heart failure; 3. Patients with degree II-III atrioventricular block or sinus bradycardia (preoperative sinus rhythm is less than 50 beats/min) or recent use of beta-blockers; 4. Patients with severe liver and kidney insufficiency (plasma albumin content should be greater than 35g/L); 5. Ventilation dysfunction such as pulmonary infection or sleep apnea syndrome; 6. Menstrual women, pregnant women, hearing impairment, elderly dementia or mental disorders unable to cooperate; 7. People who take narcotic analgesics, sedatives, antidepressants, anticonvulsants, drugs of abuse, and alcoholism in the past year; 8. People with allergies to remazolam hydrochloride, lidocaine, ropivacaine, or bupivacaine; 9. Refuse to participate and be included in the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect chamber transport rate constant;System execution error; | — |
Countries
China
Contacts
Public ContactJianjin Li
Peking University Shenzhen Hospital
Outcome results
None listed