Depressive disorder
Conditions
Interventions
1:active DLPFC tDCS
2:sham DLPFC tDCS
Sponsors
Shanghai Mental Health Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years; 2. Meeting the criteria of the Diagnostic and Statistical Manual of Mental Disorder (DSM-5) for treatment current unipolar MDD, which is assessed by at least one professional psychiatrist; 3. Han ethnicity; 4. Right handedness; 5. With a score >= 17 on the 17-item Hamilton Depression Rating Scale (HAMD-17); 6. With a score >= 6 on the Beck Scale of Suicidal Ideation (BSI); 7. Without any pharmacotherapy at baseline or maintaining actual pharmacotherapy for at least 2 weeks before the stimulation initiation and during the total stimulation period.
Exclusion criteria
Exclusion criteria: 1. Assessed through applying the Mini-International Neuropsychiatric Interview (MINI) by professional psychiatrists that diagnosed any other current or past psychiatric axis-I disorders (except MDD in the patients); 2. Acute or chronic renal failure, cirrhosis or active hepatopathy; 3. Any clinically significant abnormal laboratory examination that may influence the health of participants; 4. A history of any aignificant medical illness such as neurological disorders (such as cerebral trauma, seizure disorder, etc); 5. Current alcohol and drug abuse; 6. Pregnant women or lactation; 7. Abnormal scalp such as open wounds; 8. Recently taking benzodiazepines and anti-epileptic mood stabilizers (5 half-life of the drug as standard); 9. MDD patients with the treatment in any form prior to the study; 10. There were other conditions that were deemed by the investigator to be inappropriate for participation in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Beck Scale for Suicide Ideation; | — |
Countries
China
Contacts
Public ContactYiming Chen
Shanghai Mental Health Center
Outcome results
None listed