chronic obstructive pulmonary disease
Conditions
Interventions
control group:normal saline
Sponsors
Xiangyang First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Diagnostic criteria for COPD; 2. Aged 18-75 years; 3. BMI <= 30 kg/m2; 4. Airflow limitation grading II-III (mMRC grading) in patients with stable COPD; 5. History of exposure to risk factors for chronic obstructive pulmonary disease and currently away from exposure factors; 6. In a stable phase, free of respiratory infections and acute exacerbations in the last 4 weeks; 7. History of at least 2 acute exacerbations or 1 hospitalization for acute exacerbations in the last 12 months.
Exclusion criteria
Exclusion criteria: 1. Concomitant significant hemoptysis; 2. Other concomitant active or clinically significant respiratory disease with significant study impact; 3. Previous pneumonectomy or lung decompression within 12 months prior to screening; 4. Within 1 month of screening, enrolled or planning to enroll in a pulmonary disease rehabilitation program; 5. Current regulated use of oral glucocorticoids; 6. Patients with associated malignancies; 7. With severe cardiac, hepatic, or renal system disease; 8. Pregnant or lactating women, or women planning to become pregnant during the study period; 9. Unable to communicate normally and incapacitated, making it difficult to assess the effectiveness and safety of the treatment; 10. In the opinion of the investigator, unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulmonary Function Tests; | — |
Secondary
| Measure | Time frame |
|---|---|
| CT of the chest;St.George's Respiratory Questionnaire;EuroQol five-dimensional questionaire;COPD self-assessment test;6 minute walking test;modified British medical research council;Acute exacerbation of chronic obstructive pulmonary disease; | — |
Countries
China
Contacts
Public ContactBin Pei
Xiangyang First People's Hospital
Outcome results
None listed