breast disease
Conditions
Interventions
control group:pectoral nerve block
EP group:esketamine combined with pectoral nerve block
Sponsors
Department of Anesthesiology, Cangzhou Central Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18-64 years; 2. ASA grade I-II; 3. BMI 18-25 kg/m2; 4. No infection at the puncture site; 5. No history of chronic pain; 6. No pain medication taken at 24h prior to surgery; 7. No history of mental or psychological diseases; 8. No history of adverse reactions to esketamine treatment; 9. No history of allergy to local anesthetic drugs; 10. No history of lung disease; 11. No obvious abnormality in preoperative chest CT; 12. No language and communication disorders.
Exclusion criteria
Exclusion criteria: 1. Hypertension grade III; 2. Acute coronary syndrome; 3. Pulmonary hypertension; 4. Hyperthyroidism; 5. Intracranial hypertension; 6. Glaucoma; 7. A monoamine oxidase inhibitor used.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recovery Quality Score;Health-Related Quality of Life Score;Numeric Rating Scales;Score of Brief Pain Inventory;Score of Postoperative Chronic Pain;Incidence of Postoperative Chronic Pain;The Occurrence of Persistent Pain after Surgery;The Occurrence of Postoperative Pain Syndrome; | — |
Secondary
| Measure | Time frame |
|---|---|
| Central Sensitization Score;Anxiety and Depression Score;Psychological Distress Score;Brain-derived neurotrophic factor;serum inflammatory cytokine levels;5-hydroxytryptamine;Cell Immunology-Related Indicators; | — |
Countries
China
Contacts
Public ContactCui Xiuling
Department of Anesthesiology, Cangzhou Central Hospital
Outcome results
None listed