Target controlled concentration of dexmedetomidine during moderate sedation in elderly patients and its effect on surgical stress

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200063123

Enrollment

Unknown

Registered

2022-08-31

Start date

2022-09-01

Completion date

Unknown

Last updated

2023-04-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Group D:A dose of dexamethyl-controlled infusion

Group C:Saline infusion

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients undergoing elective lower extremity surgery; 2. Aged >65 years; 3. BMI 18 ~ 28kg/m^2; 4. ASA grade I ~ ?; 5. No history of neurological or psychiatric diseases; 6. No obvious abnormality of cardiopulmonary function; 7. No surgical contraindications, no contraindications of intravertebral anesthesia, able to actively cooperate with treatment.

Exclusion criteria

Exclusion criteria: 1. Confirmed cerebrovascular diseases; 2. Severe arrhythmia; 3. Taking drugs that affect the central nervous system; 4. History of allergic reaction to the study drug; 5. Pregnant or lactating patients.

Design outcomes

Primary

Measure	Time frame
Bispectral index (BIS);Improved vigilance/sedation (MOAA/S) score;Arterial blood indicators;Venous blood indicators;	—

Secondary

Measure	Time frame
Adverse reactions;General indicators;	—

Countries

China

Contacts

Public ContactCao Jianfang

Second Affiliated Hospital of Soochow University

caojianfang1972@126.com+86 18151081072

Outcome results