severe hip/knee diseases
Conditions
Interventions
EPO group:Using EPO and iron perioperatively
control group:Using iron perioperatively
Sponsors
Joint Surgery, Department of Orthopaedic Medicine, 4th Medical Center, PLAGH
Eligibility
Sex/Gender
All
Age
55 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 55-75 years; 2. Knee diseases require total knee replacement; 3. Primary unilateral artificial joint replacement.
Exclusion criteria
Exclusion criteria: 1. Contraindications for EPO use; 2. Contraindications of iron use; 3. Preoperative anemia, less than 120g/L in adult males and less than 110g/L in adult females; 4. Postoperative severe anemia, Hb less than 60g/L; 5. Combined with coagulopathy; 6. Combined with hematopoietic dysfunction; 7. Combined with malignant tumor and other systemic wasting diseases; 8. Combined kidney disease; 9. Previous history of myocardial infarction, pulmonary infarction and cerebral infarction; 10. Robot-assisted joint replacement.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood routine examination;Absolute reticulocyte count;D-Dimer;Vascular ultrasound of both lower limbs;Thrombelastography;International normalized ratio;Fibrinogen;Activated partial thrombin time;Thrombin activity;Thrombin time; | — |
Countries
China
Contacts
Public ContactChai Wei
Outcome results
None listed