vascular cognitive impairment (VCI)
Conditions
Interventions
case series:None
Sponsors
Beijing Tiantan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-80 years; 2. Meet any of the following conditions: (1) Patients with small cerebral vascular disease: 1) Age range: 50-80 years old; 2) Diagnostic criteria for CSVD: moderate to severe leukoencephalopathy (Fazekas deep >1 score or paraventricular >2 score); Or mild leukoencephalopathy (Fazekas deep =1 point or paraventricular =2 points) with lacunae or microbleeding; (2) Patients with acute ischemic stroke: 1) Duration of onset <=14 days; 2) According to the 2013 American AHA/ASA New Definition of Stroke, clinically diagnosed cases of acute ischemic stroke are defined as follows: acute onset; Focal brain/spinal/retinal nerve dysfunction; Symptoms and signs persist for more than 24 hours; Exclude non-vascular lesions; Pathological or imaging evidence excluded cerebral hemorrhage and other lesions, confirming the responsible ischemic focus; 3. Able to complete questionnaire survey, physical examination, head MRI and other medical examinations; 4. Voluntarily participate in this survey and subsequent investigations, provide biological samples, and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Meet any of the following conditions: (1) Patients with small cerebral vascular disease: stroke events in the past 6 months; (2) Patients with acute ischemic stroke: receiving intravenous thrombolysis, intra-arterial thrombectomy and bridging therapy within the time window of the acute phase; Or diagnosed with dementia before stroke; 2. Patients with pregnancy, malignant tumor, vital organ failure or life expectancy less than 3 years; 3. Patients with congenital mental impairment or other serious neurological or mental diseases; 4. Severe vision or hearing impairment may not cooperate with neuropsychological evaluators; 5. There are contraindications for MRI examination (such as metal implant, claustrophobia, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognition;Mental behavior;Imaging changes; | — |
Countries
China
Contacts
Public ContactXu Jun
Outcome results
None listed