heart valve disease
Conditions
Interventions
Group 1 :
Group 2:
Sponsors
Tianjin Chest Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. New York Heart Association (NYHA) Class II and above; 2. Definition of BVF: Permanent valve structural degeneration that causes hemodynamic changes or valve leaflet dysfunction, including calcification, valve leaflet thickening, tearing, wear, stent shedding, permanent thrombosis and other reasons. Patients with stage 2 and above structural valvular degeneration should receive a second operation: patients with moderate or greater stenosis or insufficiency of the valve caused by reversible thrombus should be excluded; Valve pressure difference > 40 mmHg), accompanied by a decrease in effective valve area and a change in flow velocity (peak flow velocity > 4 m/s); 3. STS (Society of Thoracic Surgeons, STS) score >= 4%.
Exclusion criteria
Exclusion criteria: 1. Valve function recovery after standard anticoagulant therapy; paravalvular disease; 2. Combined with severe coronary artery disease requiring revascularization or evidence of acute myocardial infarction within one month (Q wave myocardial infarction, or non-Q wave myocardial infarction, accompanied by CK-MB >= twice the normal value or T elevation); 3. Left ventricular ejection fraction < 20%; 4. Recent cerebral embolism; 5. Renal failure (serum creatinine clearance < 20 ml/min); 6. Hemorrhagic constitution or coagulation dysfunction, sepsis; 7. Life expectancy < 1 year; 8. There are uncontrolled atrial or ventricular arrhythmias.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 30 day mortality;Prosthesis-patient mismatch; | — |
Countries
China
Contacts
Public ContactNan Jiang
Tianjin Chest Hospital
Outcome results
None listed