Schizophrenia
Conditions
Interventions
Group 1 :Olanzapine oral dissolution film
Group 2:ziprasidone injection
Group 3:haloperidol injection
Sponsors
The Third Hospital of Fuyang
Eligibility
Sex/Gender
Male
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18-60 years old, regardless of gender. 2. Meet the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, 5th Edition) diagnostic criteria for schizophrenia; 3. There are agitation symptoms; 4. Primary school or above; 5. Understand the content of the study, be willing to participate in this study, and sign a written informed consent.
Exclusion criteria
Exclusion criteria: 1. Suffering from other severe mental disorders that meet the DSM-5 diagnostic criteria, including organic mental disorders, alcohol dependence, drug dependence/abuse, depression, bipolar disorder, etc.; 2. Hypertensive patients with poor blood pressure control (SBP >= 140 mmHg or DBP >= 90 mmHg at screening and baseline visit); 3. Unable to provide informed consent; 4. Women who are pregnant or breastfeeding; 5. Positive urine toxicology screening at screening or at baseline; 6. Those with previous organic brain lesions or severe brain trauma; 7. Patients with severe heart, liver and kidney insufficiency, metabolic diseases and other serious physical diseases; 8. Clinically significant electrocardiogram (ECG) abnormalities at the time of screening, including sinus bradycardia (resting heart rate = 450 ms, women >= 470 ms), history of congenital long QT syndrome, or risk of torsades de pointes due to family history of sudden death, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive and Negative Symptom Scale;General Impression of Clinical Outcome Scale;Episodic Aggressive Behavior Scale, Extrapyramidal Parasympathetic Reaction Scale;UKU Side Effects Scale; | — |
Countries
China
Contacts
Public ContactShu Cui
The Third Hospital of Fuyang
Outcome results
None listed