Chronic Kidney Disease
Conditions
Interventions
Group 1 :
Group 2:
Sponsors
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Male or female age >= 18 years old; 2. The patient visited the Nephrology Department of Ruijin Hospital from January 2011 to December 2021; 3. The patient is diagnosed with CKD; 4. The patient is diagnosed with type 2 diabetes; 5. Urinary protein level 300-3500 mg/24 hours; 6. eGFR >= 20 ml/min1.73m2 (CKD-EPI formula); 7. There are 2 24-hour urine protein inspection records with an interval of 6 months; 8. All patients received a stable dose of ACEi/ARB for at least 1 month before enrollment, and continued treatment throughout the analysis process; 9. Patients in the DAPA group were treated with dapagliflozin for 6 months on the basis of stable dose ACEi/ARB therapy; 10. Patients in the control group continued to receive stable doses of ACEi/ARB therapy for 6 months after enrollment.
Exclusion criteria
Exclusion criteria: 1. Type 1 diabetes; 2. Received high-dose steroid hormones (especially prednisone > 10 mg/day) and/or immunosuppressant therapy within 4 weeks before enrollment; 3. Autoimmune kidney disease, monoclonal globulin-related kidney disease and hereditary kidney disease (polycystic kidney disease, Fabry, Alport, etc.); 4. Severe liver disease (such as acute hepatitis, chronic active hepatitis, liver cirrhosis) before enrollment, and abnormal liver function before enrollment (liver enzymes were 3 times higher than normal); 5. Myocardial infarction, revascularization or cerebrovascular accident occurred within 3 months before enrollment; 6. Have a history of surgery within 3 months before enrollment; 7. Diagnosed with NYHA IV heart failure at the time of enrollment; 8. Pregnant or breastfeeding women at the time of enrollment; 9. Have received dialysis or kidney transplantation; 10. Combined with malignant tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24h urine protein;glucose; | — |
Countries
China
Contacts
Public ContactNan Chen
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Outcome results
None listed