allergic rhinitis
Conditions
Interventions
Group 1 :exosome intrnasal administration
Sponsors
Nanjing Drum Tower Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria of the Guidelines for the Diagnosis and Treatment of Allergic rhinitis (2015, Tianjin); 2. Aged 18-65 years; 3. Ineffective or ineffective treatment with standardized antiallergic drugs (including continuous local glucocorticoids, local and oral antihistamines, nasal irrigation, etc.); 4. Voluntarily sign the informed consent, understand and accept the duration of the study, and be able and willing to comply with all requirements, including the planned treatment, follow-up, and other study procedures.
Exclusion criteria
Exclusion criteria: 1. Other diseases of nasal cavity and paranasal sinuses (such as nasal polyps, chronic rhinitis, chronic sinusitis, frame structure malformation, etc.); 2. Pregnancy, diagnosis of autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, etc.; 3. Suffering from serious systemic diseases, such as tumors, gastrointestinal ulcers, diabetes, tuberculosis, mental diseases, etc.; 4. Syphilis, leprosy, tuberculosis and other specific infections; 5. Subjects using immunosuppressive agents for a long time; 6. Subjects who have participated in other clinical trials in the past months; 7. Subjects deemed inappropriate to participate in this clinical study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood routine examination;Serum specific IgE;Serum inflammatory factors;Nasal lavage fluid inflammatory factors;Symptom visual analogue scale score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Life quality score;Endoscopy;Olfactometry; | — |
Countries
China
Contacts
Public ContactChenjie Yu
Nanjing Drum Tower Hospital
Outcome results
None listed