Fungal infection
Conditions
Interventions
Posconazole treatment group:None
Sponsors
The First Affiliated Hospital of Medical College Xi'an jiaotong University
Eligibility
Sex/Gender
All
Age
13 Years to 69 Years
Inclusion criteria
Inclusion criteria: 1. Voluntary test, the patient or his authorized client agree to participate in the clinical trial and sign the informed consent form; 2. Aged >= 13 years, gender is not limited; 3. Patients enrolled should meet the three following criteria at the same time: (1) Liver failure criteria: 1) The diagnostic criteria in the 2018 Chinese Guideline for diagnosis and treatment of liver failure: a) Patients with pre-liver failure stage, specific symptoms include extreme fatigue, and severe gastrointestinal symptoms such as obvious anorexia, vomiting and abdominal distension; b) Alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) increased significantly, and jaundice was progressive Deepen (85.5=17.1 µmol/L; c) Hemorrhage tendency, 40% < PTA <= 50%(INR<1.5). 2) patients with moderate or severe degree of liver impairment using Child-Pugh scoring system; (2) Neutrophil count<1.0*10^9/L; (3) patients after liver transplantation or patients with decompensated liver cirrhosis; 4. Using posaconazole enteric-coated tablets to prevent fungal infection and at least 2 times posaconazole blood concentration monitoring; 5. Contraception or no possibility of pregnancy.
Exclusion criteria
Exclusion criteria: 1. Patients allergic to posaconazole enteric-coated tablets; 2. Patients who cannot eat; 3. Pregnancy / breastfeeding; 4. Expected survival time <72 hours; 5. History of drug abuse or alcohol dependence; 6. Any predictable increase in patient risk or other factors that can interfere with clinical trial outcomes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma concentration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Posaconazole adjusted dose and plasma concentration; | — |
Countries
China
Contacts
Public ContactChen Tianyan
The First Affiliated Hospital of Medical College Xi'an Jiaotong University,277 West Yanta Road, Xi'an, Shaanxi
Outcome results
None listed