Liver cirrhosis
Conditions
Interventions
Treatment group:Live Combined Bifidobacterium and Lactobacillus Tablets
Control group:No probiotics administered
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Aged 18 to 75 years; 2) Diagnosed with liver cirrhosis; 3) Receive elective TIPS.
Exclusion criteria
Exclusion criteria: 1) Severe underlying conditions involving vital organs (heart, lung, kidney, brain, hematologcial system, etc.); 2) History of overt hepatic encephalopathy or overt hepatic encephalopathy diagnosed at enrollment; 3) Previous treatments with TIPS or surgical shunt; 4) Prescribed with probiotics or prebiotics within 4 weeks before enrollment; 5) Hepatic myelopathy or other neuropsychological disorders; 6) Presence of malignancy; 7) Liver transplantation; 8) In pregnancy or lactation; 9) Poor literacy to recognize, comprehend and write simple words; 10) Complicaitons of liver cirrhosis (spontaneous bacterial peritonitis, hepatorenal syndrome, hepatopulmonary syndrome, etc.) is uncontrolled or stable less than 1 week; 11) Incompetent of reading due to compromised vision 12) Residency in high altitudes (higher than 2500 meters above the sea level); 13) Child-Pugh score exceeds 12 points or aminotransferase elevations exceeds five times of upper limits of normal; 14) Cholestatic diseases (primary biliary cirrhosis, primary sclerosing cholangitis, extrahepatic bile duct obstruction, etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hepatic encephalopathy;Gut microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| Death, liver transplantation, and other liver cirrhosis complications;Biochemical and metabolic variables, etc; | — |
Countries
China
Contacts
Public ContactHao Wu
Outcome results
None listed