dry eye
Conditions
Interventions
Experimental group:Total Glucosides of Paeony Capsules
Control group:None
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Age =18 to =75 years old (up to the screening date); (2) Diagnostic criteria for dry eye in accordance with the Expert Consensus of Dry Eye in China: Examination and Diagnosis (2020); And moderate to severe dry eyes. (3) Those who did not participate in any drug test within 3 months before inclusion; (4) Understand the whole process of the test, voluntarily participate in and sign the informed consent;
Exclusion criteria
Exclusion criteria: (1) pregnant women, women planning pregnancy or breast-feeding; (2) Patients with a history of chronic diarrhea or peptic ulcer within the past 1 year; (3) patients with uncontrolled severe hypertension and metabolic diseases (such as diabetes); (4) patients suffering from malignant tumors; (5) persons suffering from acute and or chronic infectious diseases; (6) persons with mental disorders, history of alcohol abuse, drug or other substance abuse; (7) Patients with a history of allergy to any component of the drugs or tests intended for use in the study (e.g., total glucosides of paeonia lactiflora capsules, fluorescein, lisamine green); (8) systemic use of glucocorticoids during the study period; (9) have other conditions that researchers consider not to be included in the clinical trial, such as lacrimal duct obstruction;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ocular surface disease index score;Corneal staining score and conjunctiva staining score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time of tear film rupture stained by fluorescein;Schirmer ? test;Height of the river of tears; | — |
Countries
China
Contacts
Public ContactGuigang Li
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed