Overweight or obese patients undergoing routine painless gastroscopy combined with enteroscopy
Conditions
Interventions
Group Ciprofol: Ciprofol Injection
Group Propofol:Propofol Injection
Sponsors
shanghai jiaotong Univercity School of Medicine, Renji Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age = 18 years old, = 80 years old, regardless of gender; 2. Patients undergoing elective gastroenteroscopy; 3. ASA is classified as level I or level II; 4. BMI=23kg/m2 5. It is estimated that the operation time of gastroenteroscopy will not exceed 30min; Clearly understand and voluntarily participate in the study, and sign the informed consent form by himself or his family.
Exclusion criteria
Exclusion criteria: 1. Endoscopic diagnosis and treatment techniques with complex operations are required (such as cholangiopancreatography, endoscopic ultrasonography, endoscopic mucosal resection, endoscopic submucosal dissection, oral endoscopic muscle dissection, etc.); 2. Patients to be intubated; 3. SpO2 = 95% after entering the room; 4. Definitely diagnosed as sleep apnea syndrome; 5. Weight <40kg 6. Have serious heart diseases such as severe arrhythmia, heart failure, Alzheimer's syndrome, unstable angina pectoris, myocardial infarction in recent 6 months, history of tachycardia / bradycardia requiring drug treatment, third degree atrioventricular block or QTCF interval = 450ms (corrected according to fridericia's formula) or exercise tolerance <4mets; 7. Systolic blood pressure = 180mmhg or / and diastolic blood pressure = 110mmhg measured in the endoscope room; 8. Respiratory insufficiency, history of obstructive pulmonary disease, history of bronchospasm requiring treatment within 3 months, acute respiratory infection within 1 week, and obvious symptoms such as fever, wheezing, nasal congestion and cough; 9. There is a history of uncontrolled diseases with significant clinical significance, such as liver, kidney, blood system, nervous system or metabolic system, which the researchers judge may not be suitable to participate in the study; 10. Pregnant or lactating women; 11. People who are known to be allergic to eggs, bean products, opioids and their rescue drugs, propofol, etc; 12. Participated in clinical trials of other drugs as subjects within 3 months; 13. Have a history of alcoholism within 3 months, i.e. drinking more than 2 units of alcohol per day (1 unit =360ml beer or 45ml Baijiu or 150ml wine with 40% alcohol); 14. Those with brain injury, possible convulsion, myoclonus, intracranial hypertension, cerebral aneurysm and cerebrovascular accident; Patients with schizophrenia, mental retardation, mania, insanity, long-term use of psychotropic drugs, drug addiction, history of cognitive dysfunction, etc; 15. The researcher believes that patients should not participate in this trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BMI;SpO2; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart Rate;Breathe Rate;SpCO2; | — |
Countries
China
Contacts
Public ContactWeifeng Yu
Outcome results
None listed