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Single nuclear RNA and spatial transcriptome sequencing of FCD and TSC

Sequencing analysis of single nuclear transcriptome and spatial transcriptome in focal cortical dysplasia and tuberous sclerosis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200062953
Enrollment
Unknown
Registered
2022-08-25
Start date
2022-09-01
Completion date
Unknown
Last updated
2023-04-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Focal cortical dysplasia and tuberous sclerosis

Interventions

lesion group:Focal cortical dysplasia or nodular sclerosis
control group:Normal tissue removed by extensive resection

Sponsors

The First Medical Center of PLA General Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
3 Years to 12 Years

Inclusion criteria

Inclusion criteria: ? 3-12 years old; ? The clinical manifestations and imaging examinations such as pet and MRI were consistent with the characteristics of FCD; ? Epileptic children whose lesions were located in the same lobe; ? According to ILAE criteria, patients with pathological diagnosis of the same type; ? Patients with written informed consent for surgery; ? In strict accordance with the principle of epilepsy treatment, no drug abuse.

Exclusion criteria

Exclusion criteria: ? Exclude those who do not agree to participate in the experiment; ? In addition to the diagnosis of focal cortical dysplasia, there are other major brain diseases.

Design outcomes

Primary

MeasureTime frame
single nuclear transcriptome and spatial transcriptome;—

Countries

China

Contacts

Public ContactYang Guang
yangg301@sina.com+86 13810192267

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026