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Accuracy of probe-based confocal laser endomicroscopy (pCLE) compared to random biopsies during endoscopic surveillance of Barrett’s esophagus

Accuracy of probe-based confocal laser endomicroscopy (pCLE) compared to random biopsies during endoscopic surveillance of Barrett’s esophagus

Status
Active, not recruiting
Phases
Phase 4
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200062926
Enrollment
Unknown
Registered
2022-08-24
Start date
2022-08-25
Completion date
Unknown
Last updated
2023-04-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Barrett's esophagus

Interventions

Sponsors

Beijing Friendship Hospital Affiliated to Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Subjects who can participate in this study must meet all the following criteria: 1. Age 18-75 years old, gender unlimited 2. Patients diagnosed as BE endoscopically or histopathologically 3. Voluntarily participate in this study and sign the informed consent form

Exclusion criteria

Exclusion criteria: Subjects should not participate in the study if in any of the following conditions 1. Previously diagnosed with esophageal cancer 2. Those who have previously received BE endoscopic treatment or BE surgery 3. Serious heart disease or serious respiratory disease 4. Suspected of shock, peritonitis, esophageal or gastrointestinal perforation 5. Acute stage of corrosive esophageal injury 6. Acute severe throat disease 7. Severe esophageal varices 8. Patients with obvious thoracic abdominal aortic aneurysm 9. Patients with acute cerebrovascular disease 10. Those who are taking or have a history of taking anticoagulant drugs and severe anemia (blood routine examination hemoglobin < 50g / L) 11. Patients who are allergic to fluorescein sodium 12. Patients who cannot tolerate upper gastrointestinal endoscopy under general intravenous anesthesia 13. Pregnant or lactating women 14. Patients with mental illness cannot cooperate with the examination 15. Patients who have participated in other clinical trials within 30 days 16. Other patients who researchers think are not suitable to participate in this study

Design outcomes

Primary

MeasureTime frame
Coincidence rate between pathological results of targeted biopsy guided by pCLE and pathological results of random biopsy. ;

Countries

China

Contacts

Public ContactShutian Zhang
zhangshutian@ccmu.edu.cn010-63139352

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026