Postoperative pain
Conditions
Interventions
Intervention group 1 :0.1mg/kg/h Esketamine
Intervention group 2:0.2mg/kg/h Esketamine
Intervention group 3:0.3mg/kg/h Esketamine
Sponsors
Affiliated Cancer Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: A, age: 18-65 years old b, ASA:I III c, BMI (kg/m2): 18-30 d, patients who intend to undergo abdominal surgery under general anesthesia and the expected operation time is 2 hours to 4 hours; e, informed consent has been signed
Exclusion criteria
Exclusion criteria: a, patients with mental illness; b, patients with severe risk of elevated blood pressure or intracranial pressure; c, patients with high intraocular pressure, glaucoma or penetrating ocular trauma; d, patients with poorly controlled or untreated hypertension, patients with resting systolic / diastolic blood pressure more than 180mm Hg e, patients with hyperthyroidism without treatment or insufficient treatment; f, patients with hypersensitivity to ketamine, propofol and opioids. g, patients with unstable ischemic heart disease; h, patients with cardiac insufficiency (NYHA cardiac function grade >= 3), previous cerebral infarction, severe liver disease (such as liver failure) or chronic renal failure (glomerular filtration rate < 30ml/min); i, have participated in other clinical trials
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24 hours after operation, the resting state and the proportion of moderate and severe pain during exercise.; | — |
Secondary
| Measure | Time frame |
|---|---|
| the time of extubation of endotracheal tube, the time of awakening from anesthesia and the time of leaving the operating room;Intraoperative opioid dose;Adverse reactions of opioids within 3 days after operation;the time of recovery of gastrointestinal function after operation;Time to get out of bed for the first time after operation; 24-hour postoperative recovery quality scale score (QoR-15);postoperative hospital stay (days) and total hospitalization cost; | — |
Countries
china
Contacts
Public Contactyiqianglin
Outcome results
None listed