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A randomized grouping trial: Determination the optimal time interval of programmed intermittent epidural administration for labor analgesia using 10ml-fixed bolus volume, 0.0625% ropivacaine plus 0.4 ug/ml dexmedetomidine

A randomized grouping trial: Determination the optimal time interval of programmed intermittent epidural administration for labor analgesia using 10ml-fixed bolus volume, 0.0625% ropivacaine plus 0.4 ug/ml dexmedetomidine

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200062918
Enrollment
Unknown
Registered
2022-08-23
Start date
2022-08-23
Completion date
Unknown
Last updated
2023-04-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epidural labor analgesia

Interventions

0.0625% ropivacaine +0.4µg/ml dexmedetomidine 40min group:Time interval: 40 minutes
0.0625% ropivacaine +0.4µg/ml dexmedetomidine 50min group:Time interval: 50 minutes
0.0625% ropivacaine +0.4µg/ml dexmedetomidine 60min group:Time interval: 60 minutes
0.0625% ropivacaine +0.4µg/ml dexmedetomidine 70min group:Time interval: 70 minutes

Sponsors

Zhejiang Xiaoshan Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: (1) Women aged 18 to 40; (2) ASA Level 2-3; (3) Gestational age >=37 weeks; (4) Cervical dilation 3-7cm; (5) NRS>3(0= no pain, 10= most pain).

Exclusion criteria

Exclusion criteria: (1) Intraspinal anesthesia contraindications; (2) Allergic to local anesthetics or dexmedetomidine; (3) bradycardia; (4) Refusal to sign the informed consent form; (5) Other conditions: history of cesarean section, long-term use of sedatives or analgesics.

Design outcomes

Primary

MeasureTime frame
The effective rate of each time group (40min group, 50min group, 60min group, 70min group).;

Secondary

MeasureTime frame
Each stage of labor time.;The use of analgesic pump drugs and the number of patient-controlled compressions.;Basic information of maternity;NRS (before analgesia, 30min, 60min, complete uterine opening, fetal delivery).;The basic vital signs and sensory motor block scores of the parturients.;Mode of delivery;side effect;Neonatal Apgar score;

Countries

China

Contacts

Public ContactZhong Mei
meizhong@zju.edu.cn+86 18969979723

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026