Obesity
Conditions
Interventions
Intervention group:Diacerein and lifestyle intervention
Control group:Placebo and lifestyle intervention
Sponsors
Affiliated Hospital of Nanjing University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Fully understand this study and voluntarily sign informed consent; Willing to follow and able to complete all procedures of the trial; 2. Meet the diagnostic criteria of simple obesity; 3. Aged >= 18 years old, <= 60 years old, male or female; 4. No other relevant weight loss treatment within 6 months before treatment.
Exclusion criteria
Exclusion criteria: 1. Those who do not meet the above inclusion criteria; 2. Hypothyroidism, hypercortisolism, and other secondary obesity; 3. Pregnant or lactating women or nearly 6 months have a pregnancy plan; menstrual women are not excluded; 4. Suffering from severe cardiovascular and cerebrovascular diseases, liver and kidney system diseases, hematopoietic system diseases, mental illness, etc.; 5. Have a history of allergy to diacerein or anthraquinone derivatives; 6. Patients with diarrhea such as inflammatory bowel disease, intestinal obstruction or pseudo-obstruction, and patients with unknown causes of abdominal pain; 7. Vital signs, three major routines, liver and kidney function, electrolytes, thyroid dysfunction patients; 8. Participate in other clinical studies and received investigational drugs or device treatment; 9. Currently taking therapeutic drugs affect the treatment parameters (hypoglycemic drugs, such as metformin, DPP-4 inhibitors, GLP-1 receptor agonists, acarbose, sulfonylureas, glinides, thiazolidinediones, SGLT2 inhibitors, insulin, etc.; lipid-lowering drugs, such as statins, fibrates, ezetimibe, etc.); 10. Use of antibiotics, glucocorticoids, immunosuppressive agents 3 months before the study; 11. HbA1c > 6.5% and/or FBG >= 7 mmol/L and/or PBG (120 min) >= 11.1 mmol/L; plasma cortisol (8:00) > 441 nmol/L; 12. Patients cannot complete this study or fail to comply with the requirements of this study according to the investigator's judgment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body mass index;Weight;Waist circumference; | — |
Secondary
| Measure | Time frame |
|---|---|
| TCM syndrome score;Acanthosis nigricans score;Lifestyle score;Inbody related indicators;Glucose metabolism indicators;Lipid metabolism indicators;Transient elastography of liver;Three items of thyroid function;Plasma cortisol (8:00);Adipocytokine indicators;Inflammatory factor indicators; | — |
Countries
China
Contacts
Public ContactWenbing Shang
Affiliated Hospital of Nanjing University of Traditional Chinese Medicine
Outcome results
None listed