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Frozen-warmed embryo transfer after 6 or 7 days of progesterone administration for day 6 blastocysts in hormone replacement therapy cycles: a randomized controlled trial

Frozen-warmed embryo transfer after 6 or 7 days of progesterone administration for day 6 blastocysts in hormone replacement therapy cycles: a randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200062901
Enrollment
Unknown
Registered
2022-08-23
Start date
2022-09-12
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Female infertility

Interventions

Group A:Embryos are transferred after 6 days of progesterone supplementation
Group B:Embryos are transferred after 7 days of progesterone supplementation

Sponsors

Guangdong Women and Children Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. Age at the time of oocyte retrieval between 20 and 40 years; 2. Having single frozen-thawed blastocyst transfer in HRT cycles; 3. Both husband and wife fully understand and voluntarily participate in the study.

Exclusion criteria

Exclusion criteria: 1. Recurrent spontaneous abortion; 2. Recurrent implantation failure; 3. Endometrial thickness on the day of progesterone administration =1.5 ng/ml; 5. Oocyte or sperm donor; 6. Uterine abnormalities and intrauterine adhesion; 7. GnRH agonist pre-treatment; 8. Women were also excluded if they had conditions associated with adverse pregnancy outcomes, such as hypertension and diabetes mellitus; 9. Core data missing.

Design outcomes

Primary

MeasureTime frame
Live birth rate;

Secondary

MeasureTime frame
Biochemical pregnancy rate;Clinical pregnancy rate;Early miscarriage rate;Ectopic pregnancy rate;Multiple pregnancy rate;Neonatal outcome;Perinatal complications;

Countries

China

Contacts

Public ContactLiu Fenghua

Guangdong Women and Children Hospital

liushine2006@163.com+86 13926478318

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026