Uremia
Conditions
Interventions
Treatment group:Intravenous sodium thiosulfate
Control group:no
Sponsors
The First Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Maintenance hemodialysis patients aged 18-80 years and dialysis vintage of at least 6 months; 2. CT show coronary artery calcification; 3. Accompanied by pruritus.
Exclusion criteria
Exclusion criteria: 1. Uremic patients are allergic to sodium thiosulfate; 2. Acute inflammatory disease, active malignant tumor, and life expectancy < 6 months; 3. Pregnant women and women in childbearing period who are unable to take effective contraceptive measures; 4. Currently receiving corticosteroids and vitK antagonists; 5. Other diseases causing spruritus; 6. Atrial fibrillation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coronary artery calcification score;Duo's modified pruritus score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Alanine aminotransferase;Total protein;Albumin;Total cholesterol;Triglyceride;Low density lipoprotein cholesterol;High density lipoprotein cholesterol;High sensitivity C-reactive protein;Parathyroid hormone;Bone alkaline phosphatase;25-OH vitamin D;ß2 microglobulin;Fibeoblast growth factor 23;Fetuin A;Klotho;Kt/V; | — |
Countries
China
Contacts
Public ContactLin Hongli
The First Affiliated Hospital of Dalian Medical University
Outcome results
None listed