Infertility
Conditions
Interventions
observation group:Preimplantation genetic testing for structural rearrangements (PGT-SR) among individuals with chromosomal structural abnormalities. All retrieved oocytes underwent conventional IVF.
Sponsors
Guangdong Women and Children Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: If the subject’s number of retrieved oocytes is = 14, cIVF insemination will be used (Study 1). If the subject’s number of retrieved oocytes is > 14, half of the oocytes will undergo cIVF insemination and the other half ICSI insemination (final enrollment status will be based on actual conditions) (Study 2). Other inclusion criteria are as follows: 1.Female age between 20 and 40 years inclusive; 2.One partner is a carrier of a chromosomal balanced translocation, Robertsonian translocation, or inherited inversion; 3.Male partner has normal sperm parameters according to WHO 2021 criteria; 4.Consent to single blastocyst frozen embryo transfer.
Exclusion criteria
Exclusion criteria: 1.On the day of oocyte retrieval, the male partner's semen parameters meet the criteria for ICSI; 2.Endometrial thickness < 7 mm; 3.Severe uterine factors affecting clinical outcomes: reproductive tract or uterine malformations, untreated hydrosalpinx, etc.; 4.Patients requiring concurrent PGT-M; 5.Use of donor sperm/oocytes or frozen sperm/oocytes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live birth rate;Blastocyst euploidy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| carrier detection ratio;Clinical pregnancy rate;Ongoing pregnancy rate;Early pregnancy loss rate;Fertilization rate;High qualified embryo rate on day 3;Blastocysts available for biopsy;Parental DNA contamination rate;Blastocyst ploidy status;Timing of blastocyst formation;Total fertilization failure rate;Maternal complications;Neonatal outcomes;Proportion without available blastocysts for biopsy; | — |
Countries
China
Contacts
Public ContactFenghua Liu
Guangdong Women and Children Hospital
Outcome results
None listed