Stroke
Conditions
Interventions
Stroke group:LF-rTMS
Healthy group:LF-rTMS
Sponsors
Huashan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. First-ever stroke (cerebral hemorrhage or cerebral infarction), the course of the disease is 2 weeks to 6 months; 2. Cerebral infarction meets the 2014 diagnostic criteria of the Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke, and the cerebral hemorrhage meets the 2014 diagnostic criteria of the Chinese Guidelines for the Diagnosis and Treatment of Cerebral Hemorrhage; 3. The lesion is located under the cortex, confirmed by CT or MRI; 4. Aged 18-85 years; 5. Unilateral limb hemiplegia, Brunnstrom hand = 24 points; 8. Vital signs are stable, no serious complications; 9. Informed consent signed by the patient or his immediate family member.
Exclusion criteria
Exclusion criteria: 1. There is a metal foreign body built into the head; 2. The person with a pacemaker; 3. The person with a cardiac stent; 4. The person with a cochlear implant; 5. The person with significantly increased intracranial pressure. Before TMS assessment/intervention, it is necessary to ensure that there are no metal parts inside the skull, and metal objects such as metal glasses, metal earrings, etc., of the head accessories must be removed; 6. Obvious speech, attention, hearing, vision (lateral neglect, hemianopia, etc.), intellectual, mental or cognitive dysfunction; 7. Past organic brain diseases, neuropsychiatric history, drug abuse and alcohol abuse history; 8. Severe heart, lung, liver, kidney and other important organ failure; 9. Severe cramping or pain; 10. There are metal foreign bodies in the body; those who cannot cooperate with functional assessment and have poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Motor threshold (RMT):resting/execution/motor imagery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Amplitude of motor evoked potential (MEP);central motor conduction time;Mental rotation test;motor imagery ability;Cortical Silent Period, CSP;Transcranial Magnetic Stimulation (TMS) Mapping; | — |
Countries
China
Contacts
Public ContactHewei Wang
Huashan Hospital Affiliated to Fudan University
Outcome results
None listed