None listed
Conditions
Interventions
A:elderly patients between 65 and 74 years old
B:elderly patients >= 75 years old
Sponsors
The Affiliated Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 65 years, male and female; 2. Patients scheduled for gastroscopy; 3. ASA grade I-III; 4. 18 kg/? < BMI < 30 kg/?; 5. Patients clearly understand and voluntarily participate in the study, and sign the informed consent form by themselves.
Exclusion criteria
Exclusion criteria: 1. Patients who intend to undergo tracheal intubation (including laryngeal mask); 2. Acute heart failure, unstable angina, myocardial infarction occurred within 6 months before screening, resting ECG heart rate = 450 ms, female >= 470 ms; 3. Patients suffering from severe respiratory disease (obstructive sleep apnea syndrome, acute respiratory infection, acute exacerbation of chronic obstructive pulmonary disease, uncontrolled asthma, etc.); 4. Patients suffering from mental system diseases (schizophrenia, mania, bipolar disorder, confusion, etc.) and long-term use of psychiatric drugs and cognitive dysfunction; 5. Patients with expected difficult airway; 6. Anemia or thrombocytopenia: Hb = 160 mmHg or = 100 mmHg during the screening period); 9. Those who are allergic or contraindicated to benzodiazepines, opioids and other drugs and their drug components; 10. Participated in other drug clinical trials as subjects in the past 3 months; 11. The investigator believes that it is not appropriate to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 50% effective dose (ED50);95% effective dose (ED95); | — |
Secondary
| Measure | Time frame |
|---|---|
| Success rate of sedation;Incidence of Hypotension;Incidence of respiratory depression;Sedation induction time;Incidence rate of nausea and vomiting;Incidence of injection pain;Incidence of Arrhythmias; | — |
Countries
China
Contacts
Public ContactXiaohua Zou
The Affiliated Hospital of Guizhou Medical University
Outcome results
None listed