Coronary heart disease complicated with diabetes
Conditions
Interventions
Protocol treatment group:Strictly intervene blood glucose, blood pressure and blood lipids
Conventional treatment group:Treatment and management according to the guidelines
Sponsors
Union Hospital, Tongji Medical College of Huazhong University of science and technology
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. 40-75 years old, male or female; 2. Patients with coronary heart disease complicated with type 2 diabetes (confirmed by angiography); 3. Low density lipoprotein cholesterol >1.8mmol/l; 4. Signed written informed consent.
Exclusion criteria
Exclusion criteria: (1) Received coronary stent treatment in recent one year; (2) Pregnant or lactating women; (3) Decompensated stage of chronic systolic heart failure (NYHA cardiac function rating >= 3), Patients with severe cardiovascular complications such as septic shock; (4) Stroke patients in recent 1 year; (5) Patients with severe gastrointestinal diseases and liver and kidney failure; (6) Cancer patients or patients who have received radiotherapy or chemotherapy within five years; (7) Suffering from infectious diseases such as AIDS and tuberculosis; (8) Hospitalized or suffering from other serious diseases requiring immediate hospitalization; (9) Bad addicts: drug users or alcoholics (men consume alcohol >80 g / day,Women >40 g / day; (10) Disturbance of consciousness, inability to communicate normally or any mental illness; You can't take care of yourself or walk in life and those who are inconvenient to move; (11) Life expectancy <12 months; (12) Individuals with abnormal laboratory tests and clinical manifestations who are judged by the researcher to be unsuitable for participation; (13) Unwilling to participate in the trial, unwilling to change the current drug treatment plan.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary end point event; | — |
Secondary
| Measure | Time frame |
|---|---|
| Electrocardiograph;FBG(fasting blood-glucose);Glycated hemoglobin;Simple oral glucose tolerance test(OGTT);Alanine transaminase(ALT);Aspartate aminotransferase(AST);Blood Urea Nitrogen(BUN);Creatinine;Blood routine examination;Routine urine test;Fundus photographic examination;HCY(homocysteine);Total cholesterol;Triglyceride;High density lipoprotein cholesterol(HDL-C);Low density lipoprotein cholesterol(LDL-C);Height;Weight;Waist circumference;Hip circumference;Blood pressure;Pulse; | — |
Countries
China
Contacts
Public ContactHuang Kai / Huo Yong
Union Hospital, Tongji Medical College of Huazhong University of science and technology / Peking University First Hospital
Outcome results
None listed