gastroscopy
Conditions
Interventions
one:different doses of drugs
Sponsors
Zhejiang Provincial Tongde Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Perform gastroscopy; 2. Age 18-65 years old; 3. The American anesthesiologist association (ASA) is graded I-II; 4. Body mass index (body mass index, BMI) 18 ~ 28kg/m2.
Exclusion criteria
Exclusion criteria: 1. Patients with severe respiratory diseases (obstructive sleep apnea syndrome, acute respiratory infection, acute exacerbation of chronic obstructive pulmonary disease, uncontrolled asthma, etc.); 2. Evaluate patients with difficult airway (modified Mallampati score grade IV, restricted mouth opening, small mandible, nail-mental distance less than 6cm or less than three horizontal fingers of the examiner, etc.); 3. have a history of sleep apnea; 4. Patients with acute heart failure, unstable angina, and myocardial infarction within 6 months before screening; 5. Hemodynamic instability (systolic blood pressure [SBP] 180 mmHg, diastolic blood pressure DBP > 110 mmHg, peripheral blood oxygen saturation [SpO2] < 90%); 6. Liver dysfunction (aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) higher than 2.5 times the upper limit of normal, total bilirubin (TBIL) higher than 1.5 times the upper limit of normal), or renal dysfunction ( Urea or urea nitrogen above the upper limit of normal, serum creatine above the upper limit of normal); 7. Patients with mental disorders (schizophrenia, mania, bipolar disorder, mental disorders, etc.), long-term use of psychotropic drugs, and cognitive dysfunction; 8. There is a history of long-term use of psychotropic or sedative-hypnotic drugs. 9. A history of drug abuse and drinking (alcohol abuse: an average daily consumption of more than 2 units of alcohol [1 unit = 360 ml of beer or 45 ml of 40% liquor or 150 ml of wine]); 10. Pregnant or breastfeeding women, or within 3 months of family planning (including men); 11. Allergies or contraindications to benzodiazepines, opioids, propofol and their components; 12. Patients who have participated in other drug trials within 3 months before the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED90 of cyclopofol combined with sufentanil in adult gastroscopy; | — |
Countries
China
Contacts
Public ContactWang hong wei
Zhejiang Provincial Tongde Hospital
Outcome results
None listed