Effects of Ciprofol on perioperative oxidative stress in patients undergoing thoracoscopic lobectomy

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200062756

Enrollment

Unknown

Registered

2022-08-18

Start date

2022-10-01

Completion date

Unknown

Last updated

2023-04-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

oxidative stress

Interventions

Cyclophenol group:Ciprofol induces + maintenance

Propofol group:Propofol induction + maintenance

Heptafluoroalkane group:Ciprofol induction

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: This study intends to select adult patients diagnosed by CT with non-small cell lung cancer to undergo elective thoracoscopic lobotomy with OLV, and to recruit patients who meet the following inclusion criteria: 1. age 18 to 65 years; 2. ASA status I-II; 3. BMI 18.5-25 kg/m^2.

Exclusion criteria

Exclusion criteria: Exclusion criteria: 1. severe impairment of renal function and heart function (New York Heart Association Class III-IV); 2. Preoperative abnormal lung function (1 s forced expiratory volume 38?); 4. Preoperative acid-base or electrolyte imbalance; 5. Frequent intraoperative arrhythmias; 6. OLV time < 60 minutes; 7. Patients who use cigarettes or antioxidants.

Design outcomes

Primary

Measure	Time frame
GPX4;	—

Secondary

Measure	Time frame
MDA;SOD;Hemodynamic index;Respiratory function index;Routine laboratory examination;	—

Countries

China

Contacts

Public ContactHenry Hou

houyongheng@126.com+86 13906215819

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026